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Figure 1 | Molecular Brain

Figure 1

From: Alterations of the synapse of the inner retinal layers after chronic intraocular pressure elevation in glaucoma animal model

Figure 1

Verifying intraocular pressure (IOP) elevation and reduction of retinal ganglion cells (RGCs) in a chronic hypertension glaucoma model. (A) The change of IOP after cauterization in shown. The IOP of control and cauterized eyes was measured 0, 1, 4, and 8 weeks after cauterization. The IOP of the cauterized eyes was elevated to 30.4±2.10 mmHg 1 week after cauterization and remained elevated during the 8 week experimental period (31.2±2.26 mmHg). (B) Quantification of RGCs after elevation of IOP. The number of RGCs labeled with Fluorogold in control and cauterized eyes after 1, 4, and 8 weeks are shown. The loss of RGCs in the cauterized retinas relative to control (set at 100%) was approximately 97.0%, 84.6, and 67.1% at 1, 4, and 8 weeks after cauterization, respectively. Bar represents mean±SD. Student’s t-test was used for statistical evaluation. *P< 0.05 compared to the control.

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Molecular Brain

ISSN: 1756-6606