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Figure 2 | Molecular Brain

Figure 2

From: Alterations of the synapse of the inner retinal layers after chronic intraocular pressure elevation in glaucoma animal model

Figure 2

Confocal micrographs of retinal sections double-stained for synaptophysin and PKCα, a bipolar cell marker. In the control, synaptophysin was expressed in the innermost IPL and OPL (A). After intraocular pressure elevation, expression of synaptophysin was increased throughout the IPL, OPL, and innermost ONL (B and C, left panel). Co-staining with PKCα revealed that upregulation of synaptophysin occurs in bipolar cells in the innermost IPL, where they synapse with retinal ganglion cells. Expression of synaptophysin and co-staining between synaptophysin and PKCα increased in the INL and OPL after 8 weeks of IOP elevation (C, middle panel) compared with 4 weeks (B, middle panel). Magnified confocal micrographs of the innermost inner plexiform layer in hypertensive eyes at 4 (B, right panel) and 8 weeks ( C, right panel) post-surgery. Compared to the control (set to 1.0), the co-stained area significantly increased at 1, 4, and 8 weeks after IOP elevation (D). *P< 0.05 compared with the control. Scale bars=50 μm.

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