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Figure 4 | Molecular Brain

Figure 4

From: Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation

Figure 4

NMDA receptors activation promotes ER dynamics and expansion. (A) Scatter plot showing correlation between spine ER content and spine volume at t = 0 min for vehicle. (B) Equivalent plot for L689,560. (C) Cumulative probability plot of ER volume at t = 0 for vehicle and L689,560 groups (K-S test, P < 0.001). (D) Scatter plot for changes in the spine ER content as a function of changes in spine volume over the 10 min period for vehicle (calculated by dividing the difference during the 10 min period by the value at t = 0). (E) Equivalent plot for L689,560. (F) Cumulative probability plot of normalised ER volume for vehicle and L689,560 groups (K-S test, P < 0.001). (G) Changes in ER volume of growing spines for vehicle and L689,560 groups (Mann–Whitney, P < 0.05). (H) Changes in ER volume of shrinking spines for vehicle and L689,560 groups.

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