Figure 4
From: Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation
NMDA receptors activation promotes ER dynamics and expansion. (A) Scatter plot showing correlation between spine ER content and spine volume at t = 0 min for vehicle. (B) Equivalent plot for L689,560. (C) Cumulative probability plot of ER volume at t = 0 for vehicle and L689,560 groups (K-S test, P < 0.001). (D) Scatter plot for changes in the spine ER content as a function of changes in spine volume over the 10 min period for vehicle (calculated by dividing the difference during the 10 min period by the value at t = 0). (E) Equivalent plot for L689,560. (F) Cumulative probability plot of normalised ER volume for vehicle and L689,560 groups (K-S test, P < 0.001). (G) Changes in ER volume of growing spines for vehicle and L689,560 groups (Mann–Whitney, P < 0.05). (H) Changes in ER volume of shrinking spines for vehicle and L689,560 groups.