Effects of SIRT1 overexpression on the disease duration of non-transgenic, and high and low copy SOD1G93Atransgenic mice. (A) Definition of the early and late phases of the disease. (B-D) Comparison of the total (B), early (C), and late (D) phases of the disease duration. SIRT1 overexpression extended the total disease duration in the SOD1G93A-L mice by extending the late phase. The data were analyzed by one-way ANOVA following post-hoc t-tests. *, p < 0.05; **, p < 0.01.