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Figure 2 | Molecular Brain

Figure 2

From: Abnormalities in the zinc-metalloprotease-BDNF axis may contribute to megalencephaly and cortical hyperconnectivity in young autism spectrum disorder patients

Figure 2

The ZMB axis model of ASD. Synaptic zinc may be developmentally modulated by certain genetic, epigenetic, or gender risk factors for ASD. Consequent aberrant activation of metalloproteases may result in prolonged upregulation of BDNF. The resulting enhancement in neurotrophic influences may underlie brain overgrowth and hyperconnectivity, which may contribute to ASD.

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Molecular Brain

ISSN: 1756-6606