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Figure 1 | Molecular Brain

Figure 1

From: Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference

Figure 1

MP-10 suppressed the acquisition (A) but not the expression (B) of morphine CPP. (A) MP-10 (1.25-10 mg/kg, s.c.) or vehicle (2 ml/kg, s.c.) were administered 30 min before morphine (10 mg/kg, s.c.) or saline (2 ml/kg, s.c.) during the conditioning sessions. ***P < 0.001 indicates difference in comparison with saline group, whereas ##P < 0.01 indicates comparison with the morphine group. N = 6-13 per group. (B) Pretreatment of MP-10 (2.5 mg/kg) 30 min prior to placement in the apparatus on post-conditioning test day. *P < 0.05, compare with saline group, N = 6-10 per group. CPP scores were assessed as the difference of time spent in the drug-paired compartment between the post and pre-conditioning phases. Data were expressed as mean±SEM.

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