Figure 3
From: Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference
MP-10 treatment (2.5 mg/kg, s.c.) facilitates the extinction of morphine CPP. Figure (A) shows the treatment time line and figure (B) shows the results. No compartment preferences developed in rats receiving saline throughout the experimental procedure (Sal/Veh). Rats administered vehicle in extinction sessions show spontaneous extinction tendency until the third extinction test (Mor/Veh). Rats receiving MP-10 (2.5 mg/kg) exhibited complete extinction of preference by the second and third extinction test (Mor/MP-10). The place preference score is defined as the difference in time spent in drug-paired compartments. Data are expressed as mean±SEM. *P < 0.05, **P < 0.01 compared between Mor/Veh and Sal/Veh group. #P < 0.05 compared between Mor/MP-10 and Sal/Veh group. & P < 0.05 compared between Mor/Veh and Mor/MP-10. N = 6-7 per group.