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Figure 1 | Molecular Brain

Figure 1

From: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Figure 1

Spinal nerve ligation (SNL) induces mechanical allodynia and anxiety-like behaviors in rats. (A - C): pain behavior and anxiety-like behaviors. Note that SNL produces obvious pain behavior as measured by 50% paw withdrawal threshold (PWT) (A, ***p < 0.001, two-way ANOVA, n = 10 SNL, 12 sham) and anxiety-like behaviors as measured by spent time in elevated plus-maze (EPM) (B, ***p < 0.001, SNL versus sham, two-tailed unpaired t-test, n = 10 SNL, 12 sham) and open-field test (C, ***p < 0.001, SNL versus sham, two-tailed unpaired t-test, n = 18/group). (D - F): effects of intra-CeA administration of diazepam on anxiety-like behaviors and locomotor function in SNL rats. Note that diazepam (2 μg/μl) dramatically inhibits SNL-induced anxiety-like behaviors as measured by EPM test (D) and open-field test (E) and does not affect the locomotor function of rats as measured by inclined-plate test (F) (*p < 0.05, **p < 0.01, one-way ANOVA, n = 7 - 11/group).

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