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Figure 10 | Molecular Brain

Figure 10

From: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Figure 10

Effects of intra-CeA administration of muscimol (a GABA A receptors agonist) or bicuculline (a GABA A receptors antagonist) on pain behavior and anxiety-like behaviors in rats. (A - D): effects of intra-CeA administration of muscimol on pain behaviors (A), anxiety-like behaviors (B, C) and locomotor function (D) in SNL rats. Note that muscimol (25 ng/μl) significantly rescues the SNL-induced mechanical allodynia (as assessed by PWT, (A)) and anxiety-like behaviors (as assessed by elevated plus-maze (B) and open-field test (C)), but does not affect the locomotor function of rats as assessed by inclined-plate test (D). **p < 0.01, ***p < 0.001, one-way ANOVA, n = 11 - 17/group. (E - H): effects of bicuculline on pain behaviors (E), anxiety-like behaviors (F, G) and locomotor function (H) in naive rats. Note that bicuculline (25 ng/μl) induces obvious pain allodynia as measured by PWT (E, ***p < 0.001, two-way ANOVA, n = 13 - 14/group), and produces anxiety-like behavior as measured by EPM (F, *p < 0.05, bicuculline versus NS, two-tailed unpaired t-test, n = 10 - 12/group), but does not affect open-field test (G, n = 11 - 13/group). Moreover, intra-CeA administration of bicuculline does not affect locomotor function in na''ve rats as measured by inclined-plate test (H, n = 14/group).

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Molecular Brain

ISSN: 1756-6606