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Figure 3 | Molecular Brain

Figure 3

From: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Figure 3

Alteration of evoked firing patterns and reduction of spike latency in CeA neurons in SNL-induced anxiety rats. (A): representative of four different firing patterns of CeA neurons recorded in evoked discharges mode under whole-cell current-clamp recording. Action potentials are evoked by a series of 600-ms depolarizing current pulses in 10 pA increment from 0 pA to 110 pA. (B): proportions of four firing patterns in the CeA neurons in na''ve, sham and SNL rats, respectively. Note that the proportion of early firing-adapting pattern in CeA neurons is increased significantly in SNL rats compared to na''ve and sham rats. N = 52 cells from 7 na''ve rats, 36 cells from 6 sham rats, and 54 cells from 8 SNL rats, respectively. (C): summaries of spike latency in early-firing and late-firing pattern in CeA neurons in na''ve, sham and SNL rats. Note that the spike latency is decreased remarkably in late-firing neurons but not in early-firing neurons in SNL rats compared to na''ve and sham rats, #p < 0.05, compared to na''ve; *p < 0.05, compared to sham, one-way ANOVA, n = 14 - 18/group.

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Molecular Brain

ISSN: 1756-6606