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Figure 4 | Molecular Brain

Figure 4

From: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Figure 4

Increases in amplitude and duration of after depolarized potential (ADP) in CeA neurons in SNL-induced anxiety rats. (A): representative of five spontaneous action potential types (type 1 to type 5) of CeA neurons under whole-cell current-clamp recording. Red arrows show the main features of each action potential type. Detailed description is mentioned in the text. (B and C): summaries of amplitude and frequency of ADP and rest membrane potential (RMP) of the CeA neurons in na''ve, sham and SNL rats. (B): examples represent characteristics of ADP in multispike firing neurons exhibiting type 1 action potentials. Lower panel in each group: enlarged trace showing ADP of type 1 neurons. Summaries of the amplitude and frequency of ADP and RMP of type 1 neurons among na''ve, sham and SNL groups are displayed below the representative of spikes. (C): examples represent characteristics of ADP in burst-firing neurons. Lower panel: enlarged trace showing the measurement of ADP amplitude and duration. Summary of ADP duration of burst-firing neurons among three groups is displayed in the right bottom. Note that SNL induces a significant increase in both amplitude (B-left bottom, **p < 0.01, one-way ANOVA) and duration (C-right bottom, *p < 0.05, one-way ANOVA) but not frequency (B-middle, p > 0.05, one-way ANOVA) of ADP in CeA neurons. Moreover, no significant difference is observed on RMP among na''ve, sham and SNL groups (B-right bottom, p > 0.05, one-way ANOVA). N = 16 cells from 4 na''ve rats, 15 cells from 5 sham rats and 17 cells from 6 SNL rats, respectively.

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Molecular Brain

ISSN: 1756-6606