Figure 3
From: Behavioral characterization of mice overexpressing human dysbindin-1
Slightly increased responses to METH and PCP in Dys1A-Tg mice. Acute behavioral responses to METH (A and B) or PCP (C and D) were examined using locomotor (A and C), PPI (B), and object investigation (D) tests in Dys1A-Tg (closed symbols and bars) and wild-type (open symbols and bars) mice. METH or PCP were injected at 60 min and cumulative locomotor activity measured for 70 100 min was indicated in bar graphs in (A) and (C). Data are expressed as mean sEM. Number of mice for each genotype, 14±27 (A), 17±35 (B), 3 8 (C), and 3±5 (D). Statistical analysis was performed by repeated three or two-way ANOVA followed by the Tukey Kramer post-hoc test. *P < 0.05, **P < 0.01 vs. vehicle of the same genotype. #P < 0.05 vs. wild-type of the same treatment.