Figure 4
From: Behavioral characterization of mice overexpressing human dysbindin-1
Effects of chronic PCP administration in Dys1A-Tg mice. (A) The experimental schedule consisted of four successive behavioral tests (see Methods for details). (B±E) PCP was administered subcutaneously daily for 14 days, and locomotor activity measured using a digital counter system with an infrared sensor for 90 min (B), immobility time in the FST (C), duration of social interaction between two unfamiliar test mice of the same genotype and treatment (D), and object exploration time and preference index in the test session of the novel object recognition memory test on day 21 (E) were determined in Dys1A-Tg (closed bars) and wild-type (open bars) mice. Data are expressed as mean sEM. Number of mice for each genotype is 12 14 obtained from three independent cohorts. Statistical analysis was performed by two-way ANOVA followed by the Tukey Kramer post hoc test. *P < 0.05 vs. vehicle of the same genotype, #P < 0.05 vs. wild-type of the same treatment.