From: Behavioral characterization of mice overexpressing human dysbindin-1
Paradigm and examination | Wild-type | Dys1A-Tg | P value | |
---|---|---|---|---|
Appearance | ||||
 | Body weight (g) | 23.4±0.43 | 23.1±0.40 | 0.88 |
 | Body position | 4.00±0 00 | 4.00±0.00 | N.D. |
 | Respiration rate | 2.00±0.00 | 2.06±0.06 | 0.35 |
 | Heart rate | 1.06±0.06 | 1.11±0.08 | 0.62 |
 | Tremor | 0.13±0.09 | 0.11±0.08 | 0.90 |
 | Palpebral closure | 0.00±0.00 | 0.00±0.00 | N.D. |
 | Piloerection | 0.00±0.00 | 0.00±0.00 | N.D. |
 | Lacrimation | 0.00±0.00 | 0.00±0.00 | N.D. |
Motor function | ||||
 | Spontaneous activity | 3.00±0.00 | 3.00±0.00 | N.D. |
 | Transfer arousal | 3.94±0.17 | 4.00±0.16 | 0.79 |
 | Gait | 0.00±0.00 | 0.03±0.03 | 0.35 |
 | Pelvic elevation | 2.06±0.06 | 2.06±0.06 | 0.93 |
 | Tail elevation | 1.81±0.10 | 1.83±0.09 | 0.88 |
 | Trunk curl | 0.38±0.13 | 0.44±0.12 | 0.69 |
 | Limb grasping | 0.38±0.13 | 0.72±0.11 | 0.045 |
 | Grip strength | 2.56±0.13 | 2.72±0.14 | 0.44 |
 | Righting reflex | 0.00±0.00 | 0.00±0.00 | N.D. |
 | Contact reflex | 1.00±0.00 | 0.97±0.03 | 0.35 |
 | Negative geotaxis | 0.00±0.00 | 0.00±0.00 | N.D. |
Sensory function | ||||
 | Touch escape | 1.81±0.10 | 1.89±0.11 | 0.64 |
 | Positional passivity | 0.03±0.03 | 0.06±0.06 | 0.97 |
 | Visual placing | 1.88±0.09 | 1.94±0.06 | 0.48 |
 | Corneal reflex | 1.00±0.00 | 1.00±0.00 | N.D. |
 | Toe pinch | 2.75±0.11 | 2.72±0.11 | 0.86 |
Anxiety level | ||||
 | Urination | 0.38±0.13 | 0.17±0.09 | 0.18 |
 | Defecation | 2.56±0.49 | 3.00±0.58 | 0.75 |
 | Vocalization | 0.88±0.09 | 0.89±0.08 | 0.90 |
 | Provoked biting | 0.88±0.09 | 0.83±0.09 | 0.74 |