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Table 1 SHIRPA primary screening in Dys1A-Tg mice

From: Behavioral characterization of mice overexpressing human dysbindin-1

Paradigm and examination

Wild-type

Dys1A-Tg

P value

Appearance

 

Body weight (g)

23.4±0.43

23.1±0.40

0.88

 

Body position

4.00±0 00

4.00±0.00

N.D.

 

Respiration rate

2.00±0.00

2.06±0.06

0.35

 

Heart rate

1.06±0.06

1.11±0.08

0.62

 

Tremor

0.13±0.09

0.11±0.08

0.90

 

Palpebral closure

0.00±0.00

0.00±0.00

N.D.

 

Piloerection

0.00±0.00

0.00±0.00

N.D.

 

Lacrimation

0.00±0.00

0.00±0.00

N.D.

Motor function

 

Spontaneous activity

3.00±0.00

3.00±0.00

N.D.

 

Transfer arousal

3.94±0.17

4.00±0.16

0.79

 

Gait

0.00±0.00

0.03±0.03

0.35

 

Pelvic elevation

2.06±0.06

2.06±0.06

0.93

 

Tail elevation

1.81±0.10

1.83±0.09

0.88

 

Trunk curl

0.38±0.13

0.44±0.12

0.69

 

Limb grasping

0.38±0.13

0.72±0.11

0.045

 

Grip strength

2.56±0.13

2.72±0.14

0.44

 

Righting reflex

0.00±0.00

0.00±0.00

N.D.

 

Contact reflex

1.00±0.00

0.97±0.03

0.35

 

Negative geotaxis

0.00±0.00

0.00±0.00

N.D.

Sensory function

 

Touch escape

1.81±0.10

1.89±0.11

0.64

 

Positional passivity

0.03±0.03

0.06±0.06

0.97

 

Visual placing

1.88±0.09

1.94±0.06

0.48

 

Corneal reflex

1.00±0.00

1.00±0.00

N.D.

 

Toe pinch

2.75±0.11

2.72±0.11

0.86

Anxiety level

 

Urination

0.38±0.13

0.17±0.09

0.18

 

Defecation

2.56±0.49

3.00±0.58

0.75

 

Vocalization

0.88±0.09

0.89±0.08

0.90

 

Provoked biting

0.88±0.09

0.83±0.09

0.74

  1. Data are expressed as mean sEM (Dys1A-Tg, n = 18; wild-type, n = 16). P values were calculated using the Mann Whitney U test. Bold type indicates P < 0.05. N.D., not different.