Table 2 Genes with significantly altered expression in the brain of Dys1A-Tg mice
From: Behavioral characterization of mice overexpressing human dysbindin-1
Brain region/changes in Dys1A-Tg | Gene name | Gene symbol | UniGene ID | Fold change vs. wild-type | Signal intensity | |
|---|---|---|---|---|---|---|
Wild-type | Dys1A-Tg | |||||
Prefrontal cortex | ||||||
Increased | TRAF2 and NCK interacting kinase | Tnik | Mm.126193 | 1.3 ± 0.1 | 3765 ± 169 | 4742 ± 195 |
Decreased | Kruppel-like factor 10 | Klf10 | Mm.4292 | 0.6 ± 0.0 | 1055 ± 21 | 621 ± 31 |
|  | Activity regulated cytoskeletal-associated protein | Arc | Mm.25405 | 0.3 ± 0.1 | 2194 ± 442 | 644 ± 156 |
|  | early growth response 2 | Egr2 | Mm.290421 | 0.5 ± 0.1 | 633 ± 76 | 307 ± 86 |
|  | RIKEN cDNA 5330406 M23 gene | 5330406M23Rik | Mm.109877 | 0.7 ± 0.0 | 2301 ± 117 | 1502 ± 86 |
|  | Myelin transcription factor 1-like | Myt1l | Mm.253067 | 0.6 ± 0.0 | 1926 ± 154 | 1224 ± 77 |
|  | RIKEN cDNA C130075A20 gene | C130075A20Rik | ±± | 0.5 ± 0.0 | 643 ± 71 | 348 ± 21 |
|  | Integrin beta 1 binding protein 1 | Itgb1bp1 | Mm.352231 | 0.5 ± 0.0 | 343 ± 23 | 172 ± 14 |
Hippocampus | ||||||
Increased | G protein-coupled receptor 178 | Gpr178 | Mm.297552 | 1.4 ± 0.1 | 1512 ± 71 | 2169 ± 76 |
|  | Chemokine (C-C motif) ligand 21b | Ccl21b | Mm.220853 | 1.7 ± 0.1 | 874 ± 78 | 1503 ± 65 |
Decreased | zinc finger, MYM domain containing 1 | Zmym1 | Mm.273806 | 0.7 ± 0.0 | 2050 ± 64 | 1398 ± 75 |
Striatum | ||||||
Increased | TRAF2 and NCK interacting kinase | Tnik | Mm.126193 | 1.3 ± 0.1 | 3418 ± 220 | 4587 ± 232 |
Decreased | DNA segment, Chr 4, Wayne State University 53, expressed | D4Wsu53e | Mm.331964 | 0.7 ± 0.1 | 2878 ± 230 | 1863 ± 165 |
|  | Kruppel-like factor 2 (lung) | Klf2 | Mm.26938 | 0.6 ± 0.1 | 414 ± 62 | 244 ± 27 |