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Figure 3 | Molecular Brain

Figure 3

From: Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury

Figure 3

Nerve injury enhanced the GluA1 channel numbers in ACC-SC projecting neurons. (A-B) Samples showed that DiI retrograde labeling pyramidal cells in the ACC layer V was dual labeled with biocytin for injection into the SC (A) or VS (B). Bar equal to 20'µm. (C-E) Peak-scaled nonstationary fluctuation analysis (NSFA) indicated that the AMPAR channel number but not the single channel conductance was increased in ACC-SC projecting neurons in mice after nerve injury. (F-H) NSFA showed that nerve injury changed neither the AMPAR channel number nor the single channel conductance in ACC-VS projecting neurons. (I-K) Bath application of CP-AMPAR antagonist NASPM reduces the AMPAR channel number, without changing the conductance in ACC-SC projecting neurons. *, p <0.05; **, p <0.01.

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Molecular Brain

ISSN: 1756-6606