Spatial learning in the Morris Water Maze (MWM) Task was reduced in p110β-β-β-. (A) Contextual fear memory of p110β- or tdTomato-expressed mice (Flag-p110β, n = 14; tdTomato, n = 12). (B) Average escape time traveled to the hidden platform (mean α sem) in the MWM test (flag-p110β, n = 14; tdTomato, n = 12, F = 8.25, **p <0.01, repeated measures two-way ANOVA). (C) The average percentage of time spent in the target quadrant (TQ, *p <0.05, repeated measures two-way ANOVA), the opposite quadrant (OQ) and two adjacent quadrants (AQ) during the probe trial given on day 6 of the MWM task. (D) Total number of crossings of the location of the platform (**p <0.01, Student s t-test) during the probe trials.