Expression of Aβ42 in the nervous system dramatically reduces the life span. (A-B) Survival curves of the indicated genotypes expressed either with the pan-neuronal driver elav-Gal4 (A) or the driver D42-Gal4 which expresses in the glutamatergic motoneurons (B). P < 0.0001 comparing the controls elav-Gal4 and D42-Gal4 to Aβ42 expression, respectively. p = 0.0028 comparing Aβ42; D42-Gal4 and Aβ42/OK371-Gal4; D42-Gal4. Co-expression of Fz2 or RNAi-Sgg did not rescue life span. P-values are calculated with the Log-rank test.