The rough eye phenotype induced by Aβ42 is not rescued by RNAi-Sgg or Gαo [Q205L]. (A) In the control eye (Aβ42 without driver) ommatidia are arranged in a regular array. The other parental line, GMR-Gal4, also shows similar wild-type arrangement. (B) Expression of Aβ42 in the eyes with the driver GMR-Gal4 results in a rough eye phenotype. This is not rescued by co-expression of neither RNAi-Sgg (C) nor Gαo [Q205L] (D).