Figure 4
From: Cdk5/p35 functions as a crucial regulator of spatial learning and memory
Reduced dendritic spine density on pyramidal neurons in CreER-p35 cKO mice. (A) Representative segments of the dendrites of pyramidal neurons in the cerebral cortex and hippocampus. Scale bar: 50μm. (B) Higher magnified images of indicated areas of the dendrites of pyramidal neurons in the cerebral cortex and in the hippocampus. Scale bar: 10μm. (C) Dendritic spine density in the cerebral cortex and hippocampus was significantly decreased in CreER-p35 cKO (p35 cKO, black bars) compared with p35-flox (control, white bars) mice. hip: hippocampus, cc: cerebral cortex. Error bars represent S.E.M. **p<0.01, ***p<0.001.