Figure 4

Intersection of proteins derived from proteomic expression profiling of human limbic structures and synaptosomes with proteins identified in BG nuclei. (upper) Protein expression data reported in amygdala [35], hippocampus [36], olfactory bulb [37], pituitary gland [38], thalamus [39], and sustantia nigra [26],[28],[40]-[42] have been considered. Striatum dataset contains proteins detected in CN and putamen while GP dataset encompasses proteins identified in the lateral and medial segments (GPe and GPi). Numbers represent the number of shared proteins in the respective overlapping areas. (lower) Venn diagrams representing the overlap between the “synaptic proteome” composed by the three major databases on synaptic proteins (C2G, SynsysNet, and Synaptome DB) [43]-[45] and the striatal and pallidal proteomes characterized in this study.