Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus

Fernández-Irigoyen, Joaquín; Zelaya, María Victoria; Tuñon, Teresa; Santamaría, Enrique

doi:10.1186/s13041-014-0083-9

Molecular Brain

Table 1 Detection of specific protein products of major cell type markers in basal nuclei by proteomics

From: Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus

Markers	Protein products	Code	Gpe	Gpi	CN	Put.
OLs
CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase	P09543	++	++	++	++
HSPA2	Heat shock-related 70 kDa protein 2	P54652	++	++	++	++
MOG	Myelin oligodendrocyte glycoprotein	Q5STM1	++	++	++	++
PLP1	Proteolipid protein 1	A8K9L3	++	++	++	++
MBP	Isoform 3 of Myelin basic protein	P02686-3	++	---	++	++
	Myelin basic protein	P02686	---	++	---	---
BCAS1	Isoform 2 of Breast carcinoma-amplified sequence 1	O75363-2	++	---	---	---
ENPP6	Ectonucleotide pyrophosphatase/phosphodiesterase member 6	Q6UWR7	---	++	---	---
PPP1R14A	Protein phosphatase 1 regulatory subunit 14A	Q96A00	---	++	---	---
Astrocytes
ATP1A2	Sodium/potassium-transporting ATPase subunit alpha-2	B1AKY9	++	++	++	++
GFAP	Glial fibrillary acidic protein	P14136	++	++	++	++
GLUL	Glutamate-Ammonia Ligase	A8YXX4	++	++	++	++
HAPLN1	Hyaluronan and proteoglycan link protein 1	P10915	++	++	++	++
AHCYL1	Putative adenosylhomocysteinase 2	O43865	++	++	++	++
ALDOC	Fructose-bisphosphate aldolase C	P09972	---	++	++	++
SLC4A4	Solute carrier family 4 Na(+)/HCO3(-) cotransporter 4 isoform 2	Q9Y6R1-2	++	---	++	---
	Solute carrier family 4 Na(+)/HCO3(-) cotransporter 4	Q9Y6R1	---	---	---	++
	Solute carrier family 4 Na(+)/HCO3(-) cotransporter 4 variant	A5JJ20	---	++	---	---
SLC1A2	Excitatory amino acid transporter 2	P43004	++	++	---	---
	Solute carrier family 1, member 2	A2A2U1	---	---	---	++
METTL7A	Methyltransferase-like protein 7A	Q9H8H3	---	++	---	++
ALDH1L1	Cytosolic 10-formyltetrahydrofolate dehydrogenase	O75891	---	---	++	---
Neurons
PGM2L1	Glucose 1,6-bisphosphate synthase	Q6PCE3	++	++	++	++
GDA	Guanine deaminase	Q9Y2T3	++	++	---	++
	Guanine deaminase isoform 3	Q9Y2T3-3	---	---	++	---
MAP2	Isoform 3 of Microtubule-associated protein 2	P11137-3	++	++	++	++
	MAP2 protein (Fragment)	Q6NYC5	++	++	++	++
MAP1B	Microtubule-associated protein 1B	P46821	++	++	++	++
SCG2	Secretogranin-2	P13521	++	++	++	++
SNAP25	Synaptosomal-associated protein 25	P60880	++	++	++	++
SLC12A5	Solute carrier family 12 member 5	Q9H2X9	++	---	---	---
	cDNA FLJ75342, similar to solute carrier family 12 member 5	A8K143	---	++	++	++
	Isoform SNAP-25a of Synaptosomal-associated protein 25	P60880-2	---	---	++	++
PLCXD3	similar to PI-specific phospholipase C, X domain containing 3	B3KXD1	++	---	++	++
NRCAM	Isoform 2 of Neuronal cell adhesion molecule	Q92823-2	---	++	---	---
	Neuronal cell adhesion molecule	Q92823	---	---	---	++
NRXN1	Neurexin-1-alpha	Q9ULB1	---	---	++	++

(++) indicates protein evidence and (---) non-detected. Code refers to the UniProtKB/Swiss-Prot entry for each protein. OLs, Oligodendrocytes.

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