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Figure 3 | Molecular Brain

Figure 3

From: CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

Figure 3

Myelin induces an IEG response of c-Fos involving SRF. Cerebellar neurons were stimulated with total myelin for the indicated time-points followed by analysis of c-Fos protein abundance. (A) Myelin induces c-Fos after 1 and 2 h of application. At later time-points, c-Fos is down-regulated as also depicted in the quantification of an individual experiment. (B) In Srf deficient neurons, myelin fails to induce c-Fos to a similar extent as observed in wild-type neurons. (C) Myelin recruits MAP kinases and Rho-GTPase but not cAMP/PKA signaling to induce c-Fos. Numbers in bars indicate independent cell cultures analyzed.

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Molecular Brain

ISSN: 1756-6606