Figure 4

Involvement of MASC proteins in genetic diseases. A. Percentage of genes expressed in human NSB MASC, PM MASC and PSD causing central nervous system diseases included in OMIM. B. Proportion of CNS diseases caused by genes found in human NSB MASC (red), PM MASC (blue) and PSD (green). ICD-10 groups (Chapters) indicated on x-axis: Congenital Malformations refers to ICD-10 Chapter XVII, Nervous System Diseases refers to ICD-10 Chapter VI, Endocrine and metabolic refers to ICD-10 Chapter IV and Mental and Behavioural refer to ICD-10 Chapter V. Means compared by Student’s t-test. C. Genes expressed at the postsynapse causing any form of genetic Intellectual Disability (ID). For each postsynaptic protein complex pale columns indicate number of genes causing ID and dark columns the expected number to be found by chance. Binomial statistics are used to compute significance of the difference between observed and expected (Binomial Statistics, ***, p <1E-05; **, p <1E-03; *, p <0,05). D. Genes expressed at the postsynapse causing any form of genetic non-syndromic Intellectual Disability (NSID). For each postsynaptic protein complex pale columns indicate number of genes causing ID and dark columns the expected number to be found by chance. Binomial statistics are used to compute significance of the difference between observed and expected (Binomial Statistics, ***, p <1E-05; **, p <1E-03; *, p <0,05).