The impairment of cerebellar LTD at synapses between parallel fiber and Purkinje cells in
mice. (A) Superimposed PF-EPSCs recorded before (gray line) and 20 min after (black line) PF&ΔV in PCs of wild-type or Ptprr
−/− cerebellar slices. (B) Averaged time course of LTD triggered by PF&ΔV. The LTD was recorded from PCs in wild-type (n = 9) or Ptprr
−/− (n = 9) cerebellar slices. PF-EPSC amplitudes are normalized to their mean prestimulation level. (C) Amplitudes of PF-EPSCs elicited by PF stimuli of increasing intensity. (D) PPF ratios of PF-EPSCs elicited by a pair of PF stimuli with different intervals. (E) Decay time constant of PF-EPSC. Error bars represent SEM.