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Table 1 Passive properties of hippocampal pyramidal neurons cultured at high density following 48 h pharmacological treatment

From: N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity

Treatment

n

C m (pF)

R in (MΩ)

V m (mV)

CTL-H2O

31

48.8 ± 1.2

571 ± 34

−59.5 ± 0.6

TTX

20

47.1 ± 1.9

721 ± 44*

−59.8 ± 0.9

BC

9

48.0 ± 3.4

529 ± 53

−60.1 ± 1.7

APV

9

45.0 ± 1.8

787 ± 51*,#

−58.0 ± 2.1

TTX + APV

10

50.7 ± 2.4

791 ± 22**,#

−58.7 ± 0.8

TTX + Nif

9

47.4 ± 3.1

769 ± 22*,#

−58.1 ± 0.6

CTL-DMSO

12

49.3 ± 1.5

583 ± 32

−60.5 ± 0.9

Nif

9

46.8 ± 2.3

672 ± 43

−58.7 ± 0.5

STO-609

10

50.2 ± 2.0

680 ± 63

−60.7 ± 0.8

  1. n, number; Cm, Whole-cell membrane capacitance; Rin, input resistance; Vm, resting membrane potential. Each value represents the mean ± SEM (*p < 0.05, **p < 0.01 for CTL-H2O vs. drug treatment; # p < 0.05 for BC vs. other drug treatment).
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Molecular Brain

ISSN: 1756-6606