N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity

Table 2 AP properties of hippocampal pyramidal neurons cultured at high density following 48 h pharmacological treatment

Treatment	V _T (mV)	AP height (mV)	AP rise (ms)	AP decay (ms)	AP HW (ms)	fAHP (mV)	AP latency (ms)
CTL-H₂O	−39.4 ± 0.5	64.6 ± 1.3	0.70 ± 0.03	1.72 ± 0.07	1.94 ± 0.07	−19.1 ± 0.6	15.1 ± 0.72
TTX	−40.2 ± 0.7	67.4 ± 1.5	0.67 ± 0.03	1.81 ± 0.08	1.97 ± 0.10	−15.4 ± 0.7**	11.2 ± 0.58**
BC	−37.6 ± 0.4	65.4 ± 2.5	0.60 ± 0.03	1.48 ± 0.14	1.55 ± 0.10	−19.7 ± 1.4^#	14.5 ± 0.87
APV	−38.7 ± 1.5	65.6 ± 3.2	0.89 ± 0.05*^{,##,^^}	2.52 ± 0.17**^{,##,^^}	2.56 ± 0.07**^{,##,^^}	−11.5 ± 1.1**^{,^^}	12.9 ± 1.12
TTX + APV	−39.9 ± 0.7	62.8 ± 2.2	0.70 ± 0.02	1.92 ± 0.12^$	2.18 ± 0.12^{^}	−15.8 ± 0.9	12.3 ± 0.78
TTX + Nif	−38.4 ± 0.7	63.5 ± 2.3	0.62 ± 0.05^$$	1.78 ± 0.13^$$	2.04 ± 0.16	−17.6 ± 1.2^$$	11.0 ± 0.54*
CTL-DMSO	−39.0 ± 0.9	66.5 ± 1.4	0.76 ± 0.07	1.73 ± 0.19	2.04 ± 0.11	−17.9 ± 1.5	16.1 ± 1.5
Nif	−38.0 ± 0.7	68.2 ± 3.2	0.69 ± 0.05	1.92 ± 0.13	2.07 ± 0.12	−17.5 ± 0.8	16.9 ± 1.0
STO-609	−40.0 ± 0.9	69.3 ± 1.4	0.78 ± 0.05	2.14 ± 0.12	2.26 ± 0.13	−15.9 ± 0.9	16.8 ± 2.0

VT, voltage threshold for action potential; AP, Action potential; rise, 10-90% rise time of AP; decay, 10-90% decay time of AP; HW, half-width; fAHP, fast after-hyperpolarization. AP properties were measured from the first action potential evoked by a current step to 100 pA at a holding potential of −60 mV. Each value represents the mean ± SEM (*p < 0.05, **p < 0.01 for CTL-H₂O vs. drug treatment; ^# p < 0.05, ^## p < 0.01 for TTX vs. other drug treatment; ^{^} p < 0.05, ^{^^} p < 0.01 for BC vs. other drug treatment; ^$ p < 0.05, ^$$ p < 0.01 for APV vs. other drug treatment).

ISSN: 1756-6606