Heat map of miRNAs and predicted gene targets in regions of G93A-SOD1 mouse brain. Regions investigated were brainstem motor nuclei, primary motor cortex, hippocampus and SVZ at week 18. Expression data are means of log2 fold changes (relative to mean values for all brain areas investigated). Blue indicates down-regulation and red indicates up-regulation of miRNAs and predicted gene targets, respectively. Hierarchical clustering analysis identifies two clusters of miRNAs and their predicted targets: one characterizing brainstem motor nuclei and primary motor cortex (areas of neurodegeneration); the other characterizing hippocampus and SVZ (areas of neurogenesis).