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Table 1 List of gene targets for each miRNA and inverse correlations in each brain region investigated of 18-week old G93A-SOD1 mice

From: Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

miRNA

Gene target

SVZ

Hippocampus

Primary motor cortex

Brainstem motor nuclei

miR-124a

- Distal-less homeobox 2 (Dlx2)

r > − 0.5

r > − 0.5

r = − 0.96

r = − 0.96

- Jagged (Jag1)

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Sex determining region Y(SRY)-box 9 (Sox9)

r > − 0.5

r > − 0.5

r > − 0.5

r = − 0.51

- Signal transducer and activator of transcription 3 (STAT3)

r > − 0.5

r > − 0.5

r > − 0.5

r = − 0.89

miR-9

- Hairy and enhancer of split (Hes1)

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Nuclear receptor subfamily (Nr2e1)

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Phoshatase and tensin homolog (Pten)

r > − 0.5

r > − 0.5

r > − 0.5

r = − 0.54

- STAT3

r = − 0.77

r = − 0.95

r > − 0.5

r = − 0.51

miR-19a

- Cyclin D2 (Ccnd2)

r > − 0.5

r = − 0.76

r > − 0.5

r > − 0.5

- Pten

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Suppressor of cytokine signalling 1 (Socs1)

r > − 0.5

r = − 0.88

r > − 0.5

r > − 0.5

- Sex determining region Y(SRY)-box 6 (Sox6)

r = − 0.96

r > − 0.5

r = − 0.96

r > − 0.5

miR-19b

- Ccnd2

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Pten

r = − 0.85

r > − 0.5

r > − 0.5

r > − 0.5

- Socs1

r = − 0.90

r > − 0.5

r > − 0.5

r > − 0.5

- Sox6

r = − 0.83

r > − 0.5

r = − 0.96

r > − 0.5

miR-125b

- Forkhead box protein J3 (FoxJ3)

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

- Sox6

r > − 0.5

r > − 0.5

r = − 0.96

r > − 0.5

miR-219

- FoxJ3

r > − 0.5

r > − 0.5

r = − 0.96

r > − 0.5

- MAP kinase interacting serine/threonine kinase 2 (Mknk2)

r > − 0.5

r > − 0.5

r = − 0.99

r > − 0.5

- Pten

r > − 0.5

r > − 0.5

r = − 0.50

r > − 0.5

- Specific E3 ubiquitin protein ligase 1 (Smurf1)

r > − 0.5

r > − 0.5

r > − 0.5

r > − 0.5

  1. miRNA targets were predicted from published data and in-silico modeling using miRWalk database and default score parameters (http://www.umm.uni-heidelberg.de/apps/zmf/mirwalk/). Pearson’s correlation coefficients (r) were used to corroborate relationships between miRNAs and target mRNA expression levels in G93A-SOD1 mouse brain regions at week 18. Coefficients less than −0.5 (bold) were considered to indicate a good inverse correlation.