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Table 1 List of gene targets for each miRNA and inverse correlations in each brain region investigated of 18-week old G93A-SOD1 mice

From: Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

miRNA Gene target SVZ Hippocampus Primary motor cortex Brainstem motor nuclei
miR-124a - Distal-less homeobox 2 (Dlx2) r > − 0.5 r > − 0.5 r = − 0.96 r = − 0.96
- Jagged (Jag1) r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Sex determining region Y(SRY)-box 9 (Sox9) r > − 0.5 r > − 0.5 r > − 0.5 r = − 0.51
- Signal transducer and activator of transcription 3 (STAT3) r > − 0.5 r > − 0.5 r > − 0.5 r = − 0.89
miR-9 - Hairy and enhancer of split (Hes1) r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Nuclear receptor subfamily (Nr2e1) r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Phoshatase and tensin homolog (Pten) r > − 0.5 r > − 0.5 r > − 0.5 r = − 0.54
- STAT3 r = − 0.77 r = − 0.95 r > − 0.5 r = − 0.51
miR-19a - Cyclin D2 (Ccnd2) r > − 0.5 r = − 0.76 r > − 0.5 r > − 0.5
- Pten r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Suppressor of cytokine signalling 1 (Socs1) r > − 0.5 r = − 0.88 r > − 0.5 r > − 0.5
- Sex determining region Y(SRY)-box 6 (Sox6) r = − 0.96 r > − 0.5 r = − 0.96 r > − 0.5
miR-19b - Ccnd2 r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Pten r = − 0.85 r > − 0.5 r > − 0.5 r > − 0.5
- Socs1 r = − 0.90 r > − 0.5 r > − 0.5 r > − 0.5
- Sox6 r = − 0.83 r > − 0.5 r = − 0.96 r > − 0.5
miR-125b - Forkhead box protein J3 (FoxJ3) r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
- Sox6 r > − 0.5 r > − 0.5 r = − 0.96 r > − 0.5
miR-219 - FoxJ3 r > − 0.5 r > − 0.5 r = − 0.96 r > − 0.5
- MAP kinase interacting serine/threonine kinase 2 (Mknk2) r > − 0.5 r > − 0.5 r = − 0.99 r > − 0.5
- Pten r > − 0.5 r > − 0.5 r = − 0.50 r > − 0.5
- Specific E3 ubiquitin protein ligase 1 (Smurf1) r > − 0.5 r > − 0.5 r > − 0.5 r > − 0.5
  1. miRNA targets were predicted from published data and in-silico modeling using miRWalk database and default score parameters (http://www.umm.uni-heidelberg.de/apps/zmf/mirwalk/). Pearson’s correlation coefficients (r) were used to corroborate relationships between miRNAs and target mRNA expression levels in G93A-SOD1 mouse brain regions at week 18. Coefficients less than −0.5 (bold) were considered to indicate a good inverse correlation.