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Figure 3 | Molecular Brain

Figure 3

From: Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease

Figure 3

CSPalpha protein expression is reduced in Alzheimer’s disease superior temporal gyrus. (A) CSPalpha expression in post-mortem STG from patients with severe Alzheimer’s disease (n = 13; average age at death = 73.2 ± 3.4 years) and control subjects (n = 12; average age at death = 76.9 ± 2.1 years). CSPalpha expression was normalized against NSE. (B) The same samples as in panel (A) were used but CSPalpha expression was normalized against synaptophysin (severe Alzheimer’s disease, n = 13; control, n = 12). Panel (C) shows the representative western blots for 5 controls and 5 patients with severe AD. Means ± s.e.m. are shown. **, p < 0.01; ***, p < 0.001.

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