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Figure 4 | Molecular Brain

Figure 4

From: Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease

Figure 4

CSPalpha expression is increased in Alzheimer’s disease cerebellum. (A) CSPalpha expression in post-mortem cerebellum from patients with severe Alzheimer’s disease (n = 10; average age at death = 74.7 ± 4.0 years) and control subjects (n = 10; average age at death = 76.3 ± 4.2 years). CSPalpha expression was normalized against NSE. (B) CSPalpha expression in post-mortem cerebellum from patients with mild Alzheimer’s disease (n = 10; average age at death = 81.3 ± 4.1 years) and control subjects (n = 10). CSPalpha expression was normalized against NSE. (C) The same samples as in panel (A) were used but CSPalpha expression was normalized against synaptophysin. (D) The same samples as in panel (B) were used but CSPalpha expression was normalized against synaptophysin. Panel (E) shows the representative western blots for 5 controls, 5 patients with mild AD and 5 patients with severe AD. Means ± s.e.m. are shown. *, p < 0.05; **, p < 0.01.

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Molecular Brain

ISSN: 1756-6606