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Figure 5 | Molecular Brain

Figure 5

From: Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease

Figure 5

Increased CSPalpha immunostaining in Alzheimer’s disease cerebellum. Fixed cerebellar cortex sections from a patient with severe Alzheimer’s disease (B, D) and a control subject (A, C) were probed with anti-CSPalpha antibodies for analysis of CSPalpha expression. CSPalpha expression in the cerebellar cortex of the Alzheimer’s disease patient appeared higher than in the control subject. In A and B cerebellar cortex with the Purkinje cell layer and granule cells are visible in the lower right corner. There is increased immunoreactivity in the neuropil in Alzheimer’s disease as compared to an age-matched control case. In C and D the granule cells of the cerebellum show increased cytoplasmic and neuropil labeling in Alzheimer’s disease as compared to an age-matched control. Negative control images are shown in E and F (immunohistochemistry with omission of the primary antibody) and confirm the specificity of labeling in Figure 5 and Additional file 1: Figure S1. Haematoxylin counterstaining is also shown. Original magnification: 400×. Scale bars represent 20 μm.

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Molecular Brain

ISSN: 1756-6606