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Figure 6 | Molecular Brain

Figure 6

From: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors

Figure 6

Modulation of hippocampal synaptic plasticity by PAR1-induced glutamate release from astrocytes. A-C, The magnitude of LTD induced by 1 Hz stimulation (A) and 10 Hz stimulation (B), or LTP induced by theta-burst stimulation (C) in the absence (ACSF; black circles) or presence of TFLLR (TFLLR; white circles). Numbers of tested slices from at least three independent mice are indicated. D, Graph summarizing data in A-C by representing averaged fEPSP responses (mean ± s.e.m.) 50 ~ 60 min after application of each stimulation condition in the absence (ACSF; black circles) or presence of TFLLR (TFLLR; white circles). *, p < 0.05, unpaired Student’s t-test. E, Summary of paired-pulse facilitation (PPF) ratio of fEPSP responses in the absence (ACSF; black circles) or presence of TFLLR (TFLLR; white circles). ISI, inter-stimulus interval. The n numbers indicated for each group are the number of tested slices from at least five mice. F, Summary of basal fEPSP responses induced by treatment of either TFLLR to hippocampal slices of wild type mice (TFLLR) or FLRFamide to hippocampal slices of MrgA1 transgenic mice (MrgA1/FLRF) during the period indicated as a black line. G, Summary of LTD induction by applying 1 Hz (900 stimuli) to hippocampal slices of MrgA1 transgenic mice in the absence (MrgA1/ACSF; black circles) or presence of FLRFamide (MrgA1/FLRF; empty circles). H, Bar graph representing averaged % baseline of fEPSPs (mean ± s.e.m.) 50 ~ 60 min after stimulation. Numbers of tested slices from at least three independent mice are indicated within each bar. P = 0.780, unpaired two-tailed Student’s t-test.

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