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Table 2 Differentially regulated genes (DEGs) significantly associated with different behavioral responses, neuronal signaling processes and comorbid conditions

From: Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder

  q -Value Associated DEGs
Behavioral response
anxiety 4.37E-17 APP,BDNF,CCK,CNR1,CREB1,CRH,CRHR1,DRD2, FKBP5,FOS,MAPK1,NPY,NTRK2
anxiety-like behavior 3.10E-10 APP,BDNF,CCK,CRH,CRHR1,MAPK1
cognition 9.54E-24 AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1, DRD2,EP300,ERK1/2,FOS,GNAI1,HDAC3,KL,MAPK1,MAPK3,NGF,NPY,NR3C1,NTRK1,NTRK2,PI3K (complex),THRB
cognitive impairment 2.94E-10 APP,BDNF,CNR1,CRH,DRD2,LEP,NGF,NPY
conditioning 4.06E-12 APP,BDNF,CNR1,CREB1,CRHR1,DRD2,ERK1/2, GNAI1,HDAC2,MAPK1,NPY
depressive disorder 7.59E-10 APP,BDNF,CCKBR,CREB1,CRH,DRD2,FKBP5, NR3C1,NTRK1,THRB
emotional behavior 3.83E-15 APP,BDNF,CCK,CNR1,CREB1,CRH,CRHR1,DRD2, MAPK1,MAPK3,NGF,NPY,NTRK2
learning 1.25E-21 AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1,DRD2, EP300,ERK1/2,FOS,GNAI1,HDAC3,HOMER1,MAPK1,MAPK3,NGF,NPY,NR3C1,NTRK1,NTRK2, PI3K (complex),THRB
locomotion 6.56E-11 APP,BDNF,CCKBR,CNR1,CRH,CRHR1,DRD2,LEP, NGF,NR3C1,STAT3
long-term memory 1.37E-15 APP,BDNF,CREB1,CRH,DRD2,ERK1/2,GNAI1, HDAC3,MAPK1,NTRK2
memory 5.63E-20 AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1,DRD2, EP300,ERK1/2,GNAI1,HDAC3, HOMER1,MAPK1,NGF,NPY,NR3C1,NTRK1,NTRK2, PI3K (complex)
Mood Disorders 2.80E-10 AKT1,APP,BDNF,CCKBR,CREB1,CRH,DRD2, FKBP5,NR3C1,NTRK1,PLCG1,THRB
neurological signs 2.63E-11 AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1, DRD2,FOS,LEP,NGF,NPY,NTRK2,PRL
neuromuscular disease 1.45E-10 AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1,DRD2,FOS,LEP,NGF,NPY,NR3C1,NTRK2, PRL
object recognition memory 1.69E-09 APP,CNR1,EP300,HDAC3,NGF
post-traumatic stress disorder 5.32E-14 ADRA1A,ADRA1B,ADRA2A,ADRA2B,ADRA2C, ADRB1,CNR1,CNR2,DRD1,DRD2,DRD3,DRD4,DRD5,HTR1A,NR3C1,SLC6A4
recognition memory 2.36E-13 APP,CNR1,EP300,GNAI1,HDAC3,MAPK1,NGF, NR3C1
spatial learning 3.72E-10 APP,BDNF,CREB1,CRHR1,DRD2,FOS,NGF,NTRK2
spatial memory 2.95E-11 AKT1,APP,BDNF,CNR1,CREB1,DRD2,NGF,NPY, NR3C1,PI3K (complex)
Neuronal signaling and neurogenesis
activation of neurons 1.22E-10 APP,BDNF,CCK,CNR1,CRH,FOS,LEP,NGF,PI3K (complex)
atrophy of neurons 4.63E-10 APP,BDNF,NGF,NTRK1,NTRK2
axonogenesis 1.84E-11 AKT1,APP,BDNF,CCK,CREB1,DRD2,FOS,NGF,NTRK1,NTRK2
cell death of hippocampal neurons 1.51E-09 AKT1,APP,BDNF,CRHR1,DRD2,LEP,NGF, NTRK2
concentration of corticosterone 1.28E-13 APP,CNR1,CRH,CRHR1,DRD2,LEP,NPY,NR3C1, NTRK2,STAT3
concentration of cyclic AMP 3.58E-09 ADCY,APP,BDNF,CCK,CNR1,CRH,DRD2,LEP,NGF, PRL
degeneration of neurons 2.07E-09 AKT1,APP,BDNF,CNR1,CREB1,EP300,NGF,NTRK2, STAT3
dendritic growth/branching 6.77E-11 AKT1,APP,BDNF,CNR1,CRH,CRHR1,DRD2,NGF, NTRK2
depolarization of cells 1.34E-10 APP,BDNF,CCK,CRH,FOS,LEP,NPY
disorder of basal ganglia 2.28E-10 AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1,DRD2,FOS,LEP,NGF,NPY,NTRK2,PRL
excitation of neurons 4.23E-12 APP,BDNF,CCK,CRH,FOS,NGF,NPY,NTRK2
length of dendrites 1.78E-12 APP,BDNF,CRH,CRHR1,NGF,NTRK2
long-term potentiation 4.96E-15 APP,BDNF,CNR1,CREB1,CRHR1,DRD2,ERK1/2, GNAI1,HDAC2,MAPK1,MAPK3,NGF,NPY,NTRK2, PI3K (complex)
long-term potentiation of synapse 1.44E-12 APP,BDNF,CNR1,CREB1,DRD2,GNAI1,HDAC2, MAPK3,NTRK2
loss of dorsal root ganglion cells 4.01E-10 BDNF,NGF,NTRK1,NTRK2
mobilization of Ca2+ 3.95E-10 BDNF,CCK,DRD2,GNAI1,GNB2, inositol triphosphate,NGF,NPY,PI3K (complex), PLCG1,RXFP3,SRC
neuronal cell death 1.68E-15 AKT1,APP,BDNF,CNR1,CREB1,CRHR1,CTNNB1,DRD2,EP300,ERK1/2,FOS,HDAC3,LEP,MAPK1,NGF,NR3C1,NTRK1,NTRK2,PI3K (complex),SRC,STAT3
neuroprotection 4.24E-09 AKT1,APP,BDNF,CNR1,CRH,CRHR1,LEP,NGF,PI3K (complex)
neurotransmission 3.60E-17 APP,BDNF,CCK,CCKBR,CNR1,CRH,CRHR1, CTNNB1,DRD2,ERK1/2,GNAI1,HDAC2,LEP,NGF, NPY,NR3C1,SRC
proliferation of neuronal cells 2.13E-09 BDNF,CNR1,CTNNB1,DRD2,ERK1/2,LEP,NGF, NTRK2,PI3K (complex),STAT3
quantity of ACTH in blood 4.32E-09 CNR1,DRD2,NR3C1,NTRK2
quantity of neurons 4.71E-12 APP,BDNF,CREB1,DRD2,ERK1/2,LEP,NGF,NPY, NTRK1,NTRK2,PRL,THRB
quantity of pituitary cells 2.10E-11 CRH,CTNNB1,DRD2,LEP,PRL,THRB
release of acetylcholine 3.84E-09 APP,BDNF,CNR1,CRH,DRD2,NGF
release of Ca2+ 3.82E-09 AKT1,APP,BDNF,CCK,DRD2, inositol triphosphate,LEP,NGF,PI3K (complex),PLCG1,SRC
release of catecholamine 3.32E-14 APP,BDNF,CNR1,CRHR1,DRD2,LEP,NGF,NPY, NTRK1,NTRK2,PRL,SRC
release of dopamine 1.84E-11 APP,BDNF,CNR1,CRHR1,DRD2,LEP,NGF,NTRK2, PRL
release of L-glutamic acid 1.12E-11 ADCY,APP,BDNF,CCK,CNR1,CRH,DRD2,LEP,NGF, NPY
secretion of catecholamine 2.06E-12 AKT1,APP,CNR1,CRH,CRHR1,DRD2,NPY,NTRK1
secretion of corticosterone 4.27E-12 BDNF,CRH,CRHR1,DRD2,LEP,NPY
secretion of neurotransmitter 3.44E-10 CCK,CNR1,CRH,DRD2,NGF,NPY,NTRK1,NTRK2
stimulation of neurons 4.28E-13 APP,BDNF,CCK,CRH,FOS,LEP,NGF,NPY,NTRK2
synaptogenesis 2.22E-10 APP,BDNF,CREB1,CTNNB1,HDAC2,NGF,NTRK1, NTRK2
synthesis of neurotransmitter 7.69E-10 AKT1,APP,BDNF,CRH,NGF,NTRK1
synthesis of steroid 3.71E-09 APP,BDNF,CREB1,CRH,CRHR1,LEP,MAPK1,NR3C1,PI3K (complex),PRL,PROX1
Comorbid conditions
chronic inflammation 1.56E-11 ACE,ADORA2B,ADORA3,AGER,AOC3,C3,CCL5,CCR5,CD24A,CD28,CD47,CNR1,COX2,EDNRA,FABP4,FCER1A,FCER1G,FCGR1,FCGR3,GIF,HSPD1,IDO1,IL1B,ITGA2,JAK2,LBP,LTA,MIF,PDE5A,PIK3CG,PLA2G4A,PRKCA,PTGER3,PTGS2,STAT5A,STAT5B,TAC1,TGM2,TLR4,TNFRSF11A,TNFRSF1A,TNFSF11,H2-DMA,H2-DMB1,H2BFM,HADH,HNF1A,HPSE,HSPD1,HTT,ICA1,IFNGR2,IKBKG,IL12B,IL1R1,IL2,ILDR2,INPP5K,INPPL1,INSR,IRAK1,IRF1,IRS3,JAK2,KCNJ11,KHK,KRAS,LARS,LEP,LEPR,LEPROT,LIPE,LMAN1L,LPIN1,LTA, MAP3K7,MAPK8,MYD88,MYO5A,NCK1,NFKB1,NFKB2,NFKBIB,NFKB1,NFKB2,NFKBIB,RELA
myocardial infarction 6.49E-12 AKT1,AKT1,APP,CNR1,CREB1,CTNNB1,DRD2,EP300, ERK1/2,FOS,HDAC2,HDAC3,KL,LEP,MAPK1, MAPK3,NPY,NR3C1,STAT3,THRB,GPX3, SRC
hypertrophy of cardiomyocytes 6.16E-06 AKT1,EP300,HDAC2,LEP,MAPK1,PI3K (complex), STAT3
coronary artery disease 3.08E-04 APOE, CNR1,FOS,HDAC2,KL,NR3C1, LEP
metabolic disorders: types I and II diabetes 3.78E-15 AANAT,ABCC8,ACLY,ACSBG1,ACSBG2,ACSL4,ACSL6,ACVR1C,ADCY8,ADIPOR1,ADIPOR2,AGRP,AKT1,ANXA1,APAF1,APOE,ASIC2,ATM,BAD,BCAR1,CACNA1C,CAMP,CAPN8,CASP3,CBL,CCKAR,CD247,CDK2,CEBPB,CERK,CHUK,CITED1,CNR1,CNR2,CPE,CPLX3,GAD2,GCK,GH,GHRHR,GHRL,GHSR,GLP1R,GPR119,GRB2,GSK3B,GYS1,GZMB,H2DMA,H2DMB1,H2Q1,H2BFM,HADH,HNF1A,HPSE,HSPD1,HTT,ICA1,IFNGR2,IKBKG,ILDR2,INPP5K,INPPL1,INSR,IRAK1,IRS3,JAK2,KCNJ11,KHK,KRAS,LARS,LEP,LEPR,LEPROT,LIPE,LMAN1L,LPIN1,LTA,MAP2K2,MAP3K7,MAPK8,MC4R,MRAS,MTOR,MYO5A,NCK1,NGFR,NOS2,NPY,NRAS,NSMAF,OCRL,PAK1,SGK1,SH2B2,SIK2,SLC2A4,SLC2A8,SLC30A8,SMAD2,SOCS1,SORBS1,SORT1,SOS1,SOS2,SRC,STAT1,STAT3,STX1A,STXBP4,SYNJ2,SYP,TLN1,TLN2,TRADD,TRAF6,TRIB3,TRIP10,TSC1,TSC2,VAMP2,VDR,WDTC1,ZFP106
weight gain and obesity 4.33E-10 APP,BDNF,CNR1,CRH,DRD2,FOS,LEP,NPY,NTRK2, STAT3,CRK,CYB5R4,CYP27B1,DGAT1,DOK4,EGR1,EIF2AK3,EIF4EBP2,ENPP7,FADD,FAM3B,FAS,FASL,FCER1G,FFAR1,FKBP1B,FOXC2,FOXO4,FRS3,FYN,GAB1,PCLO,PCSK9,PDE3B,PDIA3,PDK1,PDPK1,PDX1,PHIP,PIAS1,PIK3C2G,PIK3CG,PIK3R5,PKLR,PKM,PLCB2,PLCZ1,PPARG,PPP1R3D,PRF1,PRKAR2B,PRKCD,PTEN,PTPN2,PTPRA,RAF1,RAPGEF4,RBP4,RELA,RETN,RHOQ,RIMS2,RIPK1,RPE65,RPS6KB2,RPTOR,RRAS2,SCAP,SCNN1G,