Isolation of TTX-resistant Na
1.8 currents in small-diameter DRG neurons. (A) Double immunofluorescence reveals the expression of Nav1.8 in peripherin-positive small-diameter DRG neurons. (B) Representative I-V curve family of currents recorded in the presence of 500 nM TTX. Cells were depolarized to a variety of potentials (−55 mV to +40 mV) from a holding potential of -60 mV, to elicit Nav1.8 currents. (C)
I-V curve of Nav1.8 currents shown in (B). (D) Representative traces of Nav1.8 currents elicited by a single pulse of −15 mV.