DEX dose-dependently inhibits Na
1.8 currents. (A, B) Typical traces illustrating the Nav1.8 currents in small-diameter DRG neurons recorded pre- (control) and post- (DEX) perfusion of DEX and wash out. (C) Dose-effect curve of DEX-induced inhibition of Nav1.8 currents. The currents were measured after a 1-min application of different concentrations of DEX.