Figure 1

The schematic image regarding the function of orexin in post -stroke. This image presented that the function of orexin on pathogenesis after stroke such as inflammation, memory dysfunction, and depression. In inflammation caused by ischemic stress, orexin modulates the cytokine’s production to reduce the oxidative stress and stimulates the immune cells against post-stroke induced inflammation. In cognitive decline caused by stroke, orexin alleviates the learning impairment by regulating the secretion of neurotransmitters and also attenuates the memory loss by increasing the neurogenesis. In depression caused by stroke, orexin plays a beneficial role by accelerating the production of BDNF and facilitating the increase of long term potential.