GRP78 overexpression strengthened resistance of PC12 cells to OGD. (A) The LV-GRP78-PC12 cells were observed under a light (left) and fluorescent (right) microscope, scale bar = 100 μm. (B) The GRP78 expression increased in the LV5- GRP78-PC12 cells. The control, LV-vector, LV-GRP78-PC12 were harvested and subjected to Western blotting analysis. (C), (D) Control, LV-vector, LV-GRP78-PC12 were exposed to OGD for 10 h. The cell viability was examined with CCK8 (C) and an optical microscope (D). The bar represents the ratio of the OGD groups of control, LV-vector, LV-GRP78-PC12 cells versus their respective controls. Bar represents mean ± SD, n = 3. **P < 0.01, ***P < 0.001 compared with LV- vector.