Figure 3
From: The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates
Acute antagonism of mGluR5 on dorsolateral striatum increases locomotor activity. Graphs show distance traveled (A) and the percentage of distance traveled in the center of the apparatus (C) by mice injected with either vehicle (n = 6) or MPEP (n = 6) measured at 5 min intervals. Graphs show total distance traveled (B) and the percentage of distance traveled in the center (D) by mice injected with either vehicle (n = 6) or MPEP (n = 6) cumulative over 60 min. Animals were placed in the open field box after 10 min of either vehicle (DMSO 50%) or MPEP (25 nmol/0.5 μL/side) microinfusion into the dorsolateral striatum. Each animal was monitored for 60 min. (E) Shown is a photomicrography of a representative neutral red stained coronal brain section depicting guide cannula placement according to dorsolateral striatum coordinates. (F) Graph shows latency to fall from accelerating rotarod by mice injected with either vehicle (n = 7) or MPEP (25 nmol/0.5 μL/side) (n = 7). Each animal was tested in three trials and the average latency to fall was determined. Data represent the means ± SEM. * indicates significant difference as compared to vehicle-injected mice (P < 0.05).