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Figure 5 | Molecular Brain

Figure 5

From: The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation

Figure 5

PTEN-dependent CREB dephosphorylation is critical for regulating neural stem cell differentiation. (A) NSCs transduced with GFP, PTEN RNAi, or PTEN RNAi + CREB (WT), PTEN RNAi + CREB (S133A) constructs were labeled with an antibody against the neuronal marker Tuj1. Scale bar = 40 μm. (B) Western analysis of CREB phosphorylation in control and PTEN RNAi primary cultured neurons. (C) Quantification of experiments in (A). Data are expressed as mean ± SD. *P < 0.05 **P < 0.01, ***P < 0.001 (n > 800 cells per group from each experiment).

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Molecular Brain

ISSN: 1756-6606