Figure 3

TLR2 expressed in brain parenchyma contributes to ICH-induced brain damage. WT and TLR2 KO mice (n = 5) were injected with either WT or TLR KO mouse blood (20 μl) in the striatum: WT blood injection to WT mouse (WT → WT) or to TLR2 KO mouse (WT → KO). TLR2 KO blood injection to WT mouse (KO → WT) or to TLR2 KO mouse (KO → KO). Saline (20 μl) was injected to WT mouse (saline → WT) or TLR2 KO mouse (saline → KO) as control. After 72 h, brain sections were prepared for cresyl violet staining, and hemorrhagic injury volume was calculated. Data are presented as mean ± SEM (** p < 0.01, * p < 0.05).