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Figure 11 | Molecular Brain

Figure 11

From: Characterization of Aldh2 -/- mice as an age-related model of cognitive impairment and Alzheimer’s disease

Figure 11

Lack of carbachol-induced phosphorylation of CREB in hippocampi from Aldh2 -/- mice. Hippocampal slices from 6 month old wildtype and Aldh2 -/- mice were incubated with 50 μM carbachol (+) or vehicle (-) for 30 min and snap frozen. Immunoblot analysis was performed using 30 μg protein of hippocampal homogenate, and immunoreactive bands were quantitated by densitometry. Data are presented as the mean ± SD (n = 6 mice) and were analyzed by Student’s t-test for unpaired data. ***, significant difference from basal (p < 0.001).

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