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Table 2 SHIRPA standardized battery for 6-7 month wildtype and Aldh2 -/- mice

From: Characterization of Aldh2 -/- mice as an age-related model of cognitive impairment and Alzheimer’s disease

Test

Wildtype (n = 15)

Aldh2 -/- (n = 19)

Viewing jar

  

Body position

Sitting or Standing: 15 (100%)

Sitting or Standing: 19 (100%)

Spontaneous activity

Casual Scratch, Slow Movement 15 (100%)

Casual Scratch, Slow Movement 19 (100%)

Respiration rate

Normal: 15 (100%)

Normal: 19 (100%)

Body tremor

Normal 15 (100%)

Normal: 19 (100%)

Palpebral closure

Open: 15 (100%)

Open: 19 (100%)

Piloerection

Normal: 15 (100%)

Normal: 19 (100%)

Gait

Normal: 15 (100%)

Normal: 19 (100%)

Pelvic elevation

Normal: 15 (100%)

Normal: 19 (100%)

Tail elevation

Horizontal: 15 (100%)

Horizontal: 19 (100%)

Touch escape

Mild 5 (33%)

Mild 8 (42%)

 

Moderate 10 (67%)

Moderate 11 (58%)

Positional passivity

Struggles when held tail: 15 (100%

Struggles when held tail: 19 (100%)

Trunk curl

Present: 15 (100%)

Present: 19 (100%)

Limb grasping

Present: 15 (100%)

Present: 19 (100%)

Grip strength

Active Grip, Effective: 15 (100%)

Active Grip, Effective: 19 (100%)

Body tone

Slight resistance: 15 (100%)

Slight resistance: 19 (100%)

Pinna reflex

Active Retraction: 15 (100%)

Active Retraction: 19 (100%)

Wire maneuver

  
 

Difficulty to Grasp with Hindlegs: 4 (27%)

Difficulty to Grasp with Hindlegs: 5(26%)

 

Active Grip with Hind Legs: 11 (73%)

Active Grip with Hind Legs: 14 (74%)

Skin color

Pink: 15(100%)

Pink: 19 (100%)

Abdominal tone

Slight resistance: 15 (100%)

Slight resistance: 19(100%)

Lacrimation

None 15 (100%)

None 19 (100%)

Provoked biting

Present 15 (100%)

Present 19 (100%)

Negative geotaxis

Turns and Climbs Grid 15 (100%)

Turns and Climbs Grid 19 (100%)

Handling behaviour

  

Irritability

Present 15 (100%)

Present 19 (100%)

Aggression

Present 15 (100%)

Present 19(100%)

Visual and auditory proficiency

  

Visual placing test

Before Vibrasse Contact (Visual): 15 (100%)

Before Vibrasse Contact (Visual): 19 (100%)

Preyer’s reflex test

Positive Response to Clap: 15 (100%)

Positive Response to Clap: 19 (100%)