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Figure 8 | Molecular Brain

Figure 8

From: Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis

Figure 8

Model by which Tfap2 and Ptf1a factors promote the differentiation of amacrine and horizontal cells. Tfap2a and 2b act downstream of Ptf1a to promote the differentiation of glycinergic and GABAergic amacrine cells while functioning upstream of Onecut1 and 2 for the specification of horizontal cells. Ptf1a, whose expression is activated by both Foxn4 and ROR 1, is required not only for specifying amacrine and horizontal cells in part by activating Tfap2a and 2b expression, but also for suppressing the ganglion cell fate by repressing Atoh7 expression.

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