Figure 6From: Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrusModel of 5-HT4 receptor-mediated increased neurogenesis and GC dematuration in the DG induced by chronic SSRIs. Chronic SSRI treatment induces dematuration of GCs and increases adult neurogensis via the 5-HT4 receptor (5-HT4R) in the DG. Dematured GCs exhibit an increase in expression of neurogenic factors, which may be involved in enhanced adult neurogenesis in the SGZ of the DG.Back to article page