Fig. 2
Conversion of GABAA receptor-mediated inhibition to excitation in the MNCs of lactating rats. (a) Spontaneously occurring fast GABAergic excitatory postsynaptic potentials (EPSPs, ●) and inhibitory postsynaptic potentials (IPSPs, ○) recorded in the presence of AP-5 (100 μM) and DNQX (20 μM) from the MNCs of Lac3 (upper trace) and virgin rats (lower trace). Note the action potentials that arise from the GABAergic EPSPs (upper trace). (b) Proportions of the MNCs having GABAergic EPSPs and IPSPs in different groups of rats. (**: p < 0.001, Chi-square test). n: the number of cells examined. These groups of rats were not significantly different from each other in the input resistance of MNC (Virgin: 308 ± 12 MΩ, n = 38; Lac1: 320 ± 15 MΩ, n = 30; Lac3: 303 ± 12 MΩ, n = 56; Dry3: 313 ± 12 MΩ, n = 22). (c) Depolarization and associated action potentials elicited by focal application of the GABAA agonist muscimol (10 μM; 10 ms) in an MNC of Lac3 rat