Fig. 2

Reduced pyramidal neurons in PAK1 KO P7 cortex. a, b Coronal brain sections from WT (a, c, e) and PAK1 KO (b, d, f) P7 mice were stained for the late-born neuronal marker CDP (a, b) and for early-born neuronal markers, Ctip2 (c, d) and Tbr1 (e, f), respectively. a, b, c Summary graphs of CDP, Ctip2 and Tbr1 positive neurons of WT and PAK1 KO littermates showing a significant reduction in the number of neurons in layer II-V, but not in the Layer VI of the KO mice. ***p < 0.001. **p < 0.01. Scale bars: 100 μm