Fig. 3

EAAT2 protein level is higher in the CA3 than in the CA1 region. a: The topographical distribution of EAAT2 is demonstrated in a coronal section. EAAT2 immunoreactivity is the most abundant in the CA3 region of the hippocampus and the dentate gyrus. However, EAAT2 immunoreactivity is also present in the CA1 region. b: A high magnification picture of the framed area in the CA3 region of the section shown in A is presented. Glial cell bodies are labeled in the pyramidal cell layer and adjacent part of str. oriens. Additional puncta-like labeling is seen throughout the str. radiatum and str. oriens representing astrocytic processes in these layers. c: A high magnification image of the framed area in the CA1 in A. EAAT2 immunolabeling is present in astrocytes distributed in str. oriens while faintly labeled cells are also present in str. radiatum. Scale bar = 500 μm for A and 100 μm for B and C