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Fig. 5 | Molecular Brain

Fig. 5

From: Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity

Fig. 5

Inhibition of glial K+ clearance only slightly affects IOS, but significantly decreases VSD transients. a: (Left) Representative VSD amplitude maps under control condition and 500 μM BaCl2 application. (Middle) Time course of the field potential responses and VSD transients on the diode at the field potential recording site under control condition and 500 μM BaCl2 applications. (Right) Effect of 500 μM BaCl2 on the population spike (PS) measured in the CA1 and on the average VSD and IOS amplitudes in the CA1, CA3 and DG regions. b: (Left) Representative VSD amplitude maps under control condition and 3 μM ouabain application. (Middle) Time course of the field potential responses and VSD transients on the diode at the field potential recording site under control condition and 3 μM ouabain application. (Right) Effect of 3 μM ouabain on the PS measured in the CA1 and on the average VSD and IOS amplitudes in the CA1, CA3 and DG regions. On the VSD signal amplitude maps transparent lines indicate the pyramidal cell layers (CA1 and CA3) and the granular cell layer of the DG. The positions of the stimulating and recording electrodes are marked by gray and green arrows, respectively. Asterisks indicate significant changes compared to control (P < 0.05, Mann–Whitney U test)

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