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Fig. 2 | Molecular Brain

Fig. 2

From: Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility

Fig. 2

Basal synaptic properties and long-term potentiation in wild-type and cAMP-GEF II −/− mice. a, Input–output curves as a measure of baseline excitatory synaptic transmission showed no difference between the two genotypes (WT = 8 slices from six mice; KO = 8 slices from six mice). b, Long-term potentiation (LTP) induced by high frequency stimulation (arrow, 1x HFS; 100 Hz for 1 s) was slightly impaired without statistical significance in Schaffer collateral-CA1 (SC-CA1) synapses of cAMP-GEF II −/− mice (WT = 171.54 ± 7.61 %, 8 slices from eight mice; KO = 156.74 ± 7.76 %, 8 slices from eight mice; unpaired t-test, p = 0.195). c, Paired pulse facilitation (PPF) ratio did not differ between wild-type and cAMP-GEF II −/− mice (WT = 8 slices from six mice; KO = 8 slices from six mice). d, Post-tetanic potentiation (PTP) also did not differ between wild-type and cAMP-GEF II −/− mice (WT = 8 slices from six mice; KO = 8 slices from five mice; arrow, 1x HFS). Abbreviations: fEPSP, field excitatory postsynaptic potential; HFS, high frequency stimulation

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